Reproductive Biology in Transitions
The female reproductive tract has extraordinary biological capabilities, from cyclical regeneration and robust antimicrobial defense to the immunological tolerance of an allogeneic fetus and the scarless renewal of the endometrium. Yet, despite these remarkable functions, it remains highly vulnerable to disorders such as preterm labor and fibrotic disease.
Our research focuses on two interrelated phenomena, preterm labor and scarless healing, unified by the hypothesis that microbial dysbiosis and the resulting chronic inflammation are central drivers of divergent tissue outcomes.
By leveraging primary human tissues and advanced organ-on-chip models, we aim to elucidate how epithelial, immune, and stromal interactions shape either regenerative or pathological trajectories in the female reproductive tract, ultimately bridging fundamental biology with translational advances in women’s health.
Advanced in vitro models
The basic biology of the reproductive tract still remains poorly understood. This is partially due to the vast differences in reproductive biology between different species. We are using adults stem cells to re-create human reproductive tissue niches in vitro.
Enabling translation
Disease and tissue dysfunction, such as premature contractions, are frequently physical in nature. We're utilizing bioengineering approaches to design and validate clinically relevant assays and workflows to capture these physical processes.
Disease mechanism
We use lab workflows to gain new insights into healthy and diseased states. We combine primary human cells from diseased donors, perturbation experiments (e.g., microbiome perturbations), and omics to address knowledge gaps in this area and catalyse translation in this space.
Our Vision
We are developing a toolbox of human-relevant female reproductive tract models to accelerate translation and address some of the most pressing healthcare challenges, including preterm birth and healthy aging.
Our Mission
Our lab is committed to fostering the next generation of bioengineers equipped with the skills to address global health challenges.
Developing high-fidelity models of the human female reproductive tract in transitions
Stejskalova Lab, Imperial College London, Department of Bioenginering, White City Campus (incoming: August 2026)